Pre‐ and Post Hemodialysis Procalcitonin Levels and Their Relationships with Immunoregulatory, Proinflammatory Cytokines in Chronic Hemodialysis Patients
Identifieur interne : 002831 ( Main/Exploration ); précédent : 002830; suivant : 002832Pre‐ and Post Hemodialysis Procalcitonin Levels and Their Relationships with Immunoregulatory, Proinflammatory Cytokines in Chronic Hemodialysis Patients
Auteurs : I. Karayaylali ; N. Seyrek ; M. Balal ; S. Paydas ; S. Cetiner ; A. Yaman [Turquie]Source :
- Hemodialysis International [ 1492-7535 ] ; 2004-01.
Abstract
Background/Aims: Procalcitonin (PCT) has been described as a new marker of severe infection and sepsis. In this study, we investigated the serum levels of PCT during the hemodialysis (HD) in chronically hemodialyzed patients and whether the PCT levels were correlated with other cytokines. Methods: We measured pre‐ and post‐HD PCT, interleukin (IL‐1), IL‐2, IL‐6, IL‐10, tumor necrosis factor‐α (TNF‐α) concentrations in 24 stable patients undergoing chronic HD [11 males and 13 females; age 41.2 ± 18.0 years, 12 h/week, with a Kt/V of 1.41 ± 0.35, polysynthane (PSN) membrane being used in all patients, without reuse]. Pre‐ and post‐HD PCT concentrations were compared with cytokines such as IL‐1, IL‐2, IL‐6, IL‐10, TNF‐α, and clinical parameters including age, blood pressure, leukocyte, hemoglobin levels, C‐reactive protein (CRP), epoetin (EPO) doses, BUN, creatinine, parathormone (PTH), ferritin, and transferrin levels. Results: Pre‐ and post‐HD serum PCT levels were similar (0.77 ± 0.40 and 0.83 ± 0.61 ng/mL), and higher than upper normal level of 0.5 ng/mL. The levels of IL‐2 and IL‐10 decreased and the levels of IL‐1 and TNF‐α increased. Post‐HD PCT correlated with PTH, IL‐1, IL‐2, and IL‐10. Conclusion: About 60% of patients had elevated PCT levels, HD with low‐flux PSN membrane did not change serum PCT and IL‐6. While IL‐1 and TNF‐α increased, IL‐2 and IL‐10 decreased by PSN membrane during HD. So that PCT levels can be measured just after HD as do prior to start of HD. Is there any relationship between PCT and PTH? PCT may be important in uremic bone disease.
Url:
DOI: 10.1111/j.1492-7535.2004.0085ad.x
Affiliations:
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Yaman</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:A033424656270744D777FE56E09D54C20AF99342</idno><date when="2004" year="2004">2004</date><idno type="doi">10.1111/j.1492-7535.2004.0085ad.x</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-85JPV9QH-B/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000904</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000904</idno><idno type="wicri:Area/Istex/Curation">000898</idno><idno type="wicri:Area/Istex/Checkpoint">001303</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001303</idno><idno type="wicri:doubleKey">1492-7535:2004:Karayaylali I:pre:and:post</idno><idno type="wicri:Area/Main/Merge">002840</idno><idno type="wicri:Area/Main/Curation">002831</idno><idno type="wicri:Area/Main/Exploration">002831</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Pre‐ and Post Hemodialysis Procalcitonin Levels and Their Relationships with Immunoregulatory, Proinflammatory Cytokines in Chronic Hemodialysis Patients</title><author><name sortKey="Karayaylali, I" sort="Karayaylali, I" uniqKey="Karayaylali I" first="I." last="Karayaylali">I. Karayaylali</name><affiliation><wicri:noCountry code="no comma">Department of Nephrology</wicri:noCountry></affiliation></author><author><name sortKey="Seyrek, N" sort="Seyrek, N" uniqKey="Seyrek N" first="N." last="Seyrek">N. Seyrek</name><affiliation><wicri:noCountry code="no comma">Department of Nephrology</wicri:noCountry></affiliation></author><author><name sortKey="Balal, M" sort="Balal, M" uniqKey="Balal M" first="M." last="Balal">M. Balal</name><affiliation><wicri:noCountry code="no comma">Department of Nephrology</wicri:noCountry></affiliation></author><author><name sortKey="Paydas, S" sort="Paydas, S" uniqKey="Paydas S" first="S." last="Paydas">S. Paydas</name><affiliation><wicri:noCountry code="no comma">Department of Nephrology</wicri:noCountry></affiliation></author><author><name sortKey="Cetiner, S" sort="Cetiner, S" uniqKey="Cetiner S" first="S." last="Cetiner">S. Cetiner</name><affiliation><wicri:noCountry code="no comma">Central Laboratory of Immunology and Microbiology</wicri:noCountry></affiliation></author><author><name sortKey="Yaman, A" sort="Yaman, A" uniqKey="Yaman A" first="A." last="Yaman">A. Yaman</name><affiliation wicri:level="1"><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Microbiology, Cukurova University, Adana</wicri:regionArea><wicri:noRegion>Adana</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Hemodialysis International</title><title level="j" type="alt">HEMODIALYSIS INTERNATIONAL</title><idno type="ISSN">1492-7535</idno><idno type="eISSN">1542-4758</idno><imprint><biblScope unit="vol">8</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="90">90</biblScope><biblScope unit="page" to="90">90</biblScope><biblScope unit="page-count">100</biblScope><publisher>Blackwell Science Inc</publisher><pubPlace>Oxford, UK; Malden, USA</pubPlace><date type="published" when="2004-01">2004-01</date></imprint><idno type="ISSN">1492-7535</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1492-7535</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background/Aims: Procalcitonin (PCT) has been described as a new marker of severe infection and sepsis. In this study, we investigated the serum levels of PCT during the hemodialysis (HD) in chronically hemodialyzed patients and whether the PCT levels were correlated with other cytokines. Methods: We measured pre‐ and post‐HD PCT, interleukin (IL‐1), IL‐2, IL‐6, IL‐10, tumor necrosis factor‐α (TNF‐α) concentrations in 24 stable patients undergoing chronic HD [11 males and 13 females; age 41.2 ± 18.0 years, 12 h/week, with a Kt/V of 1.41 ± 0.35, polysynthane (PSN) membrane being used in all patients, without reuse]. Pre‐ and post‐HD PCT concentrations were compared with cytokines such as IL‐1, IL‐2, IL‐6, IL‐10, TNF‐α, and clinical parameters including age, blood pressure, leukocyte, hemoglobin levels, C‐reactive protein (CRP), epoetin (EPO) doses, BUN, creatinine, parathormone (PTH), ferritin, and transferrin levels. Results: Pre‐ and post‐HD serum PCT levels were similar (0.77 ± 0.40 and 0.83 ± 0.61 ng/mL), and higher than upper normal level of 0.5 ng/mL. The levels of IL‐2 and IL‐10 decreased and the levels of IL‐1 and TNF‐α increased. Post‐HD PCT correlated with PTH, IL‐1, IL‐2, and IL‐10. Conclusion: About 60% of patients had elevated PCT levels, HD with low‐flux PSN membrane did not change serum PCT and IL‐6. While IL‐1 and TNF‐α increased, IL‐2 and IL‐10 decreased by PSN membrane during HD. So that PCT levels can be measured just after HD as do prior to start of HD. Is there any relationship between PCT and PTH? PCT may be important in uremic bone disease.</div></front></TEI><affiliations><list><country><li>Turquie</li></country></list><tree><noCountry><name sortKey="Balal, M" sort="Balal, M" uniqKey="Balal M" first="M." last="Balal">M. Balal</name><name sortKey="Cetiner, S" sort="Cetiner, S" uniqKey="Cetiner S" first="S." last="Cetiner">S. Cetiner</name><name sortKey="Karayaylali, I" sort="Karayaylali, I" uniqKey="Karayaylali I" first="I." last="Karayaylali">I. Karayaylali</name><name sortKey="Paydas, S" sort="Paydas, S" uniqKey="Paydas S" first="S." last="Paydas">S. Paydas</name><name sortKey="Seyrek, N" sort="Seyrek, N" uniqKey="Seyrek N" first="N." last="Seyrek">N. Seyrek</name></noCountry><country name="Turquie"><noRegion><name sortKey="Yaman, A" sort="Yaman, A" uniqKey="Yaman A" first="A." last="Yaman">A. Yaman</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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